Must be 21+. #1 Best Value of 24 Mexico Casino Hotels ; 2. Excite. The Pyramid Cancun · 4, reviews. DISCOVER NORTHERN NEW MEXICO AT ITS BEST! The casino is open every day. Open 24 hours, 7 days a week! What's happening. at Isleta Resort & Casino. . Saturdays in. It's a warm, friendly environment with slot machines. Our New Mexico casino is open 24/7 daily. Colorful bingo cards and round bingo balls w/numbers. No Smoking Facility. Sky City Casino is open 24 hours daily. Indulge. Win. Read More! Sky City's Main Casino and the Travel Center's Slot Area is open 24 hours daily. The Travel center includes a casino area with 45 slot machines. Sunday - Thursday: 8 AM - 2 AM | Friday & Saturday: Join the fun at Santa Ana Star Casino Hotel, the best casino in New Mexico! Located just north of Albuquerque, NM, we offer Gaming, Bowling, Golf, Dining. Seadust Cancun Family Resort · 6, reviews. Learn More. With three live entertainment venues, you'll find something around every corner. Swirls of Cash. A warm and friendly environment with slot machines at the Main Casino. Experience Vegas at Albuquerque's Sandia Casino! Test your luck at our slots or play poker, roulette & more! High limit & VIP lounge available. New Mexico has 23 Indian casinos and 4 Indian gaming travel centers located across 10 counties. Upcoming Events. Unwind. #2 Best Value of 24 Mexico. These casinos and gaming sites are owned by 14 New Mexico. 1.